Serum x - thiol protease inhibitor concentrations in health and disease
نویسندگان
چکیده
Serum a-thiol protease inhibitor (a-TPI) concentration was assayed by radial immunodiffusion in normal subjects, pregnant women, and in a wide variety of diseases. The normal concentration (448 (SD 75) mg/1) increased significantly (p < 0 001) in pregnancy to 575 (89) mg/I, and in prostatic cancer treated by oestrogens to 666 (87) mg/l. Inconsistent changes were observed in inflammatory and malignant disease and in liver disease. A temporary pronounced fall of cx-TPI was seen after burn injury, and a sustained fall after bone marrow transplantation. Crossed immunoelectrophoresis showed that the serum cx-TPI occurred in two forms, with a2 and al electrophoretic mobilities. A heavy demand on this antiprotease may result in suppression of the al form.
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